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Mbd5tm1.1Gxu
Targeted Allele Detail
Nomenclature
Symbol: Mbd5tm1.1Gxu
Name: methyl-CpG binding domain protein 5; targeted mutation 1.1, Guo-Liang Xu
MGI ID: MGI:5466579
Synonyms: Mbd5f
Gene: Mbd5  Location: Chr2:48949490-49319690 bp, + strand  Genetic Position: Chr2, 28.43 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192212
Parent Cell Line:  MPI-II (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:192212)
Generation of the Mbd5tm1.1Gxu and Mbd5tm1.2Gxu alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mbd5 Mutation:  13 strains or lines available
References
Original:  J:192212 Du Y, et al., The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One. 2012;7(10):e47358
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory