Chrm5^tm1.1Anis
Targeted Allele Detail

Summary

• Symbol: Chrm5^tm1.1Anis
• Name: cholinergic receptor, muscarinic 5; targeted mutation 1.1, Akinori Nishi
• MGI ID: MGI:5466563
• Gene: Chrm5 Location: Chr2:112309516-112311114 bp, - strand Genetic Position: Chr2, 57.02 cM
• Alliance: Chrm5^tm1.1Anis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192760
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the open reading frame and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the open reading frame. Cre-mediated recombination removed the open reading frame and the neo cassette. (J:192760)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm5 Mutation: 37 strains or lines available

References

• Original: J:192760 Kuroiwa M, et al., Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons. Neuropharmacology. 2012 Dec;63(7):1248-57
• All: 1 reference(s)