Cyp26b1^tm2Hmd
Targeted Allele Detail

Summary

• Symbol: Cyp26b1^tm2Hmd
• Name: cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 2, Hiroshi Hamada
• MGI ID: MGI:5466373
• Synonyms: Cyp26b1^{tm1.1 Mao}
• Gene: Cyp26b1 Location: Chr6:84548396-84570890 bp, - strand Genetic Position: Chr6, 36.45 cM
• Alliance: Cyp26b1^tm2Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192725
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 4 and an FRT flanked PGK-neomycin selection cassette folled by a second loxP site was inserted in the 3' untranslated region of exon 6. The selection cassette was subsequently removed by flp expression. (J:192725)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp26b1 Mutation: 35 strains or lines available

References

• Original: J:192725 Okano J, et al., Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development. J Cell Sci. 2012 Apr 1;125(Pt 7):1827-36
• All: 7 reference(s)