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Selenoptm3.1Rfb
Targeted Allele Detail
Nomenclature
Symbol: Selenoptm3.1Rfb
Name: selenoprotein P; targeted mutation 3.1, Raymond F Burk
MGI ID: MGI:5466366
Synonyms: Sepp1c
Gene: Selenop  Location: Chr15:3300249-3309992 bp, + strand  Genetic Position: Chr15, 1.84 cM
Curling and splaying of hind limbs in Selenoptm3.1Rfb/Selenoptm3.1Rfb Speer6-ps1Tg(Alb-cre)21Mgn/0 mice fed a selenium-deficient diet

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192636
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked self-excising neo cassette with a 5' loxP site was inserted downstream of exon 5. The neo cassette was either removed by flp-mediated recombination or spontaneously lost, leaving exons 2 through 5 floxed. (J:94077, J:192636)
Generation of the Selenoptm3.1Rfb allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Selenop Mutation:  19 strains or lines available
References
Original:  J:192636 Hill KE, et al., Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. J Biol Chem. 2012 Nov 23;287(48):40414-24
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory