Tg(APOE-FGF23*R176Q)#Ack
Transgene Detail
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Symbol: |
Tg(APOE-FGF23*R176Q)#Ack |
Name: |
transgene insertion, Andrew C Karaplis |
MGI ID: |
MGI:5465569 |
Synonyms: |
FGF23-TG |
Transgene: |
Tg(APOE-FGF23*R176Q)#Ack Location: unknown
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Alliance: |
Tg(APOE-FGF23*R176Q)#Ack page
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Strain of Origin: |
C57BL/6J x CBA
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(APOE-FGF23*R176Q)#Ack expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
FGF23 (8074) |
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Mutation details: This transgene consists of the human APOE promoter with exon 1 and part of exon 2 and the human FGF23 cDNA with the R176Q mutation tagged with a myc epitope followed by the APOE poly(A) and hepatic control region. The APOE promoter drives expression of FGF23 in the liver. Two lines were established however, the pound symbol (#) is used because the line is not specified and lines are pooled.
(J:93981)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:93981 Bai X, et al., Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology. 2004 Nov;145(11):5269-79 |
All: |
4 reference(s) |
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