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Transgene Detail
Symbol: Tg(APOE-FGF23*R176Q)#Ack
Name: transgene insertion, Andrew C Karaplis
MGI ID: MGI:5465569
Synonyms: FGF23-TG
Transgene: Tg(APOE-FGF23*R176Q)#Ack  Location: unknown  
Strain of Origin:  C57BL/6J x CBA
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(APOE-FGF23*R176Q)#Ack expresses 1 gene
Mutation detailsThis transgene consists of the human APOE promoter with exon 1 and part of exon 2 and the human FGF23 cDNA with the R176Q mutation tagged with a myc epitope followed by the APOE poly(A) and hepatic control region. The APOE promoter drives expression of FGF23 in the liver. Two lines were established however, the pound symbol (#) is used because the line is not specified and lines are pooled. (J:93981)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:93981 Bai X, et al., Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology. 2004 Nov;145(11):5269-79
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory