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Gatmtm1.1Isb
Targeted Allele Detail
Summary
Symbol: Gatmtm1.1Isb
Name: glycine amidinotransferase (L-arginine:glycine amidinotransferase); targeted mutation 1.1, Dirk Isbrandt
MGI ID: MGI:5465452
Synonyms: AGAT-
Gene: Gatm  Location: Chr2:122424954-122441758 bp, - strand  Genetic Position: Chr2, 60.63 cM
Alliance: Gatmtm1.1Isb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:191142
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exon 3 was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in the kidney. (J:191142)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gatm Mutation:  21 strains or lines available
References
Original:  J:191142 Choe CU, et al., L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome. Hum Mol Genet. 2013 Jan 1;22(1):110-23
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory