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Targeted Allele Detail
Symbol: Esr1tm4.1Ksk
Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Kenneth S Korach
MGI ID: MGI:5465423
Gene: Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:191182
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed TK-neo selection cassette was inserted downstream of exon 3 and a third loxP site was inserted upstream. The selection cassette was subsequently removed from properly targeted mice by cre excision leaving exon 3 flanked by loxP sites. (J:191182)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:  45 strains or lines available
Original:  J:191182 Hewitt SC, et al., Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J. 2010 Dec;24(12):4660-7
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory