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Targeted Allele Detail
Symbol: Mefvtm1Bhk
Name: Mediterranean fever; targeted mutation 1, Beverly H Koller
MGI ID: MGI:5465109
Gene: Mefv  Location: Chr16:3707215-3718124 bp, - strand  Genetic Position: Chr16, 2.18 cM
Germline Transmission:  Earliest citation of germline transmission: J:192443
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace entire coding region with a neomycin resistance (neo) cassette in reverse orientation to the gene. Northern blot analysis confirmed the absence of transcript expression in elicited peritoneal neutrophils. (J:192443)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mefv Mutation:  1 strain or line available
Original:  J:192443 Hesker PR, et al., Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1beta levels. PLoS One. 2012;7(11):e51105
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory