Tg(Itgax-HBEGF/OVA/EGFP)1Garbi
Transgene Detail

Summary

• Symbol: Tg(Itgax-HBEGF/OVA/EGFP)1Garbi
• Name: transgene insertion 1, Natalio Garbi
• MGI ID: MGI:5463655
• Synonyms: CD11c.DOG, Tg(Itgax-DTR/OVA/EGFP)1Garbi, Tg(Itgax-DTR/OVA/EGFP)1Gjh
• Transgene: Tg(Itgax-HBEGF/OVA/EGFP)1Garbi Location: unknown
• Alliance: Tg(Itgax-HBEGF/OVA/EGFP)1Garbi page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Itgax-HBEGF/OVA/EGFP)1Garbi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: For generation of CD11c.DTR BAC transgenic mice, a fusion construct composed of the DNAs for the human DTR, ovalbumin fragment containing sequences encoding amino acids 140-386, and eGFP was generated and inserted at the start codon of the CD11c gene in the BAC RPCI-24-7812. The eGFP component of the fusion protein failed to give a fluorescence signal, whereas the ovalbumin protein was expressed in DC, resulting in extensive proliferation of ovalbumin-specific CD4 (OT-II) and CD8 (OT-I) cells after transfer into the CD11c.DOG mice. (J:143470)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:143470 Hochweller K, et al., A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur J Immunol. 2008 Oct;38(10):2776-83
• All: 29 reference(s)