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Tg(Thy1-APPArc)M8Cagr
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-APPArc)M8Cagr
Name: transgene insertion M8, Caroline Graff
MGI ID: MGI:5463435
Synonyms: TgAPParc, Thy1.2-hAPParc
Transgene: Tg(Thy1-APPArc)M8Cagr  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x CBA
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-APPArc)M8Cagr expresses 1 gene
 
Mutation detailsThe Arctic mutation, an A>G nucleotide substitution resulting in a glutamic acid to glycine amino acid substitution at codon 693 (E693G), was introduced into a human cDNA of APP (695 isoform) by site-directed mutagenesis and a Kozak sequence was introduced upstream of ATG to enhance translation. This construct was placed under the control of the mouse Thy1.2 expression cassette that drives expression of the transgene specifically in neurons. Two lines were made, M7 and M8. M8 is the high expressor line and hemizygous mice have an approximately 3-fold higher expression of human APP compared to endogenous App. (J:168288)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:168288 Ronnback A, et al., Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model. Neurobiol Aging. 2011 Feb;32(2):280-92
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory