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Notch3tm1.1Dwr
Targeted Allele Detail
Nomenclature
Symbol: Notch3tm1.1Dwr
Name: notch 3; targeted mutation 1.1, Mieke Dewerchin
MGI ID: MGI:5462093
Synonyms: Notch3Arg170Cys, Notch3m
Gene: Notch3  Location: Chr17:32120820-32166880 bp, - strand  Genetic Position: Chr17, 17.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:191454
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (knock-in)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch3 Mutation:  8 strains or lines available
References
Original:  J:191454 Wallays G, et al., Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2881-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory