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Tg(Pbsn-cre/Esr1*)14Abch
Transgene Detail
Nomenclature
Symbol: Tg(Pbsn-cre/Esr1*)14Abch
Name: transgene insertion 14, Andreas Birbach
MGI ID: MGI:5461708
Synonyms: ProbasinBAC-MerCreMer
Transgene: Tg(Pbsn-cre/Esr1*)14Abch  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6NCrl
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA BAC (#RP23-456A6; containing the entire mouse probasin (Pbsn) gene) was modified to insert a MerCreMer sequence (a double fusion of the cre recombinase cDNA sequence flanked on each end with a mutated murine estrogen receptor (mer) ligand binding domain, resulting in tamoxifen-inducible cre expression) driven by the Pbsn promoter/enhancer region. The construct was microinjected into fertilized C57BL/6NCrl oocytes. Founder line 14 was established by breeding the founder, carrying 8-11 copies of the transgene, to wild-type C57BL/6J mice. (J:154786)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pbsn     Summary of all recombinase alleles driven by Pbsn. Comparative matrix view of recombinase activities
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:154786 Birbach A, et al., A Probasin-MerCreMer BAC allows inducible recombination in the mouse prostate. Genesis. 2009 Nov;47(11):757-64
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory