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Targeted Allele Detail
Symbol: Ngftm1.1Blhe
Name: nerve growth factor; targeted mutation 1.1, Barbara L Hempstead
MGI ID: MGI:5461488
Synonyms: proNgf-HA
Gene: Ngf  Location: Chr3:102469919-102521013 bp, + strand  Genetic Position: Chr3, 45.25 cM
Adult Ngftm1.1Blhe/Ngf+ mice exhibit dilated cardiomyopathy and fibrosis and this phentoype is rescued in Ngfrtm1Jae/Ngfrtm1Jae Ngftm1.1Blhe/Ngf+ mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:190893
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsNucleotide substitutions result in the amino acid substitution of lysine and arginine for two alanines at positions 120 and 121 within the furin recognition site. Cre-mediated recombination removed the FRT- and loxP-flanked neo cassette inserted upstream of the modified exon. An HA-tag was inserted in-frame before the stop codon. (J:190893)
Generation of the Ngftm1.1Blhe allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ngf Mutation:  7 strains or lines available
Original:  J:190893 Siao CJ, et al., ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. J Exp Med. 2012 Nov 19;209(12):2291-305
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory