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Targeted Allele Detail
Symbol: S1pr1tm2.1Rlp
Name: sphingosine-1-phosphate receptor 1; targeted mutation 2.1, Richard L Proia
MGI ID: MGI:5461228
Synonyms: S1pr1loxP
Gene: S1pr1  Location: Chr3:115710433-115715055 bp, - strand  Genetic Position: Chr3, 50.0 cM
Germline Transmission:  Earliest citation of germline transmission: J:86450
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a single loxP site upstream of exon 2, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:86450)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S1pr1 Mutation:  12 strains or lines available
Original:  J:86450 Allende ML, et al., G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 2003 Nov 15;102(10):3665-7
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory