Il7^tm2.1Iku
Targeted Allele Detail

Summary

• Symbol: Il7^tm2.1Iku
• Name: interleukin 7; targeted mutation 2.1, Koichi Ikuta
• MGI ID: MGI:5461219
• Synonyms: IL-7^f
• Gene: Il7 Location: Chr3:7637088-7678820 bp, - strand Genetic Position: Chr3, 2.02 cM
• Alliance: Il7^tm2.1Iku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190615
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:190615)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il7 Mutation: 33 strains or lines available

References

• Original: J:190615 Liang B, et al., Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver. J Immunol. 2012 Nov 1;189(9):4444-50
• All: 5 reference(s)