Cdh6tm1.1(cre/ERT2)Jrs
Targeted Allele Detail
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Symbol: |
Cdh6tm1.1(cre/ERT2)Jrs |
Name: |
cadherin 6; targeted mutation 1.1, Joshua R Sanes |
MGI ID: |
MGI:5461051 |
Synonyms: |
Cdh6-CreER, Cdh6tm1(cre/ERT)Jrs |
Gene: |
Cdh6 Location: Chr15:13028787-13173761 bp, - strand Genetic Position: Chr15, 6.11 cM
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Alliance: |
Cdh6tm1.1(cre/ERT2)Jrs page
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Allele Type: |
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Targeted (Inducible, Null/knockout, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Cdh6tm1.1(cre/ERT2)Jrs expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The targeting vector contained (from 5' to 3') a cDNA sequence encoding the CreER fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain) with N-terminal 6xMyc tag, followed by an FRT-flanked SV40-neo selection cassette. This was inserted into the translational start site in the first coding exon of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. Mice were crossed to reporter animals for analysis.
(J:190967)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cdh6
(mouse)
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Original: |
J:190967 Kay JN, et al., Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections. J Neurosci. 2011 May 25;31(21):7753-62 |
All: |
11 reference(s) |
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