Foxp3^{tm10.1(Casp9,-Thy1)Ayr}
Targeted Allele Detail

Summary

• Symbol: Foxp3^{tm10.1(Casp9,-Thy1)Ayr}
• Name: forkhead box P3; targeted mutation 10.1, Alexander Y Rudensky
• MGI ID: MGI:5451201
• Synonyms: Foxp3-IRES-iCasp9, Foxp3-Thy1.1, Foxp3^Thy1.1
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^{tm10.1(Casp9,-Thy1)Ayr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191041
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A construct containing an IRES, inducible Caspase-9, T2A cleaving peptide coding sequence, Thy1, polyadenylation signal sequence, and an FRT site flanked neomycin resistance gene cassette was inserted into the 3' UTR. Flp-mediated recombination removed the neo cassette. (J:191041)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 57 strains or lines available

References

• Original: J:191041 Liston A, et al., Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11903-8
• All: 41 reference(s)