Nmnat1^tm1.1Lcon
Targeted Allele Detail

Summary

• Symbol: Nmnat1^tm1.1Lcon
• Name: nicotinamide nucleotide adenylyltransferase 1; targeted mutation 1.1, Laura Conforti
• MGI ID: MGI:5450824
• Synonyms: Nmnat1^2lox
• Gene: Nmnat1 Location: Chr4:149552029-149569659 bp, - strand Genetic Position: Chr4, 79.47 cM
• Alliance: Nmnat1^tm1.1Lcon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190793
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exons 1 and 2 floxed. (J:190793)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmnat1 Mutation: 35 strains or lines available

References

• Original: J:190793 Conforti L, et al., Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration. FEBS J. 2011 Aug;278(15):2666-79
• All: 2 reference(s)