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Targeted Allele Detail
Symbol: Cx3cr1tm2.1(cre/ERT2)Litt
Name: chemokine (C-X3-C motif) receptor 1; targeted mutation 2.1, Dan R Littman
MGI ID: MGI:5450813
Synonyms: Cx3cr1CreER, CX3CR1YFP-creER
Gene: Cx3cr1  Location: Chr9:120048683-120068296 bp, - strand  Genetic Position: Chr9, 71.37 cM
Germline Transmission:  Earliest citation of germline transmission: J:205483
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exon 2 of the chemokine (C-X3-C) receptor 1 (Cx3cr1) gene with a cre/ERT2 (cre recombinase fused to an estrogen receptor ligand binding domain) coding sequence, followed by an internal ribosome entry site (IRES) and an enhanced yellow fluorescent protein (EYFP). A frt-flanked neomycin resistance cassette, in reverse orientation to the gene, was also inserted downstream of the EYFP sequence. Flp-mediated recombination excised the neomycin resistance sequence. (J:190965, J:205483)
 Tissue activity of this recombinase allele
Driver: Cx3cr1     Summary of all recombinase alleles driven by Cx3cr1. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cx3cr1 Mutation:  29 strains or lines available
Original:  J:190965 Littman DR, An inducible cre recombinase driven by Cx3cr1. MGI Direct Data Submission. 2013;
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory