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Cx3cr1tm2.1(cre/ERT2)Litt
Targeted Allele Detail
Nomenclature
Symbol: Cx3cr1tm2.1(cre/ERT2)Litt
Name: chemokine (C-X3-C motif) receptor 1; targeted mutation 2.1, Dan R Littman
MGI ID: MGI:5450813
Synonyms: Cx3cr1CreER, CX3CR1YFP-creER
Gene: Cx3cr1  Location: Chr9:120048683-120068296 bp, - strand  Genetic Position: Chr9, 71.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205483
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 2 of the chemokine (C-X3-C) receptor 1 (Cx3cr1) gene with a cre/ERT2 (cre recombinase fused to an estrogen receptor ligand binding domain) coding sequence, followed by an internal ribosome entry site (IRES) and an enhanced yellow fluorescent protein (EYFP). A frt-flanked neomycin resistance cassette, in reverse orientation to the gene, was also inserted downstream of the EYFP sequence. Flp-mediated recombination excised the neomycin resistance sequence. (J:190965, J:205483)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cx3cr1     Summary of all recombinase alleles driven by Cx3cr1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cx3cr1 Mutation:  29 strains or lines available
References
Original:  J:190965 Littman DR, An inducible cre recombinase driven by Cx3cr1. MGI Direct Data Submission. 2013;
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory