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Transgene Detail
Symbol: Tg(SOD1*L126Z)#Deng
Name: transgene insertion, Han-Xiang Deng
MGI ID: MGI:5449894
Synonyms: SOD1L126Z
Transgene: Tg(SOD1*L126Z)#Deng  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(SOD1*L126Z)#Deng expresses 1 gene
Mutation detailsThis transgene consists of the human SOD1 gene with a leucine to glutamine/glutamic acid substitution at position 126 (L126Z) in exon 5. This mutation results in a premature stop codon at 126 and produces a truncated product that lacks the C-terminal 28 amino acids. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:109458)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:109458 Deng HX, et al., Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7142-7
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory