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Tg(SOD1*A4V)A1073Gur
Transgene Detail
Nomenclature
Symbol: Tg(SOD1*A4V)A1073Gur
Name: transgene insertion A1073, Mark E Gurney
MGI ID: MGI:5449884
Synonyms: A4V
Transgene: Tg(SOD1*A4V)A1073Gur  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SOD1*A4V)A1073Gur expresses 1 gene
 
Mutation detailsThis transgene construct consists of the human SOD1 gene with an alanine to valine substitution at position 4 (A4V) in exon 1. Northern and Western analysis confirmed RNA and protein expression in the brain. This mutation alters the activity of the protein and mice show greatly reduced enzymatic activity. Two lines were made, A1073 and A1074. (J:32665)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:32665 Gurney ME, et al., Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149]. Science. 1994 Jun 17;264(5166):1772-5
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory