Six1tm2.1Mair
Targeted Allele Detail
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Symbol: |
Six1tm2.1Mair |
Name: |
sine oculis-related homeobox 1; targeted mutation 2.1, Pascal Maire |
MGI ID: |
MGI:5449750 |
Synonyms: |
Six1flox |
Gene: |
Six1 Location: Chr12:73088601-73093486 bp, - strand Genetic Position: Chr12, 30.34 cM
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Alliance: |
Six1tm2.1Mair page
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Impaired tissue repair in regenerated Six1tm2.1Mair/Six1tm2.1Mair Pax7tm1(cre/ERT2)Gaka/Pax7+ muscles
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:190460
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted into the 5' end of exon 1. An FRT-flanked neo cassette with a 3' loxP site and downstream dsRed gene was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed.
(J:190460)
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Generation of the conditional Six1tm2.1Mair and delta Six1tm2.2Mair alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Six1 Mutation: |
18 strains or lines available
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Original: |
J:190460 Le Grand F, et al., Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol. 2012 Sep 3;198(5):815-32 |
All: |
11 reference(s) |
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