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Tg(Neurod1-cre)1Able
Transgene Detail
Nomenclature
Symbol: Tg(Neurod1-cre)1Able
Name: transgene insertion 1, Andrew B Leiter
MGI ID: MGI:5449711
Synonyms: NeuroD1-Cre
Transgene: Tg(Neurod1-cre)1Able  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsHomologous recombination introduced the sequence encoding cre recombinase into the translational initiation ATG codon of the Neurod1 gene located in a BAC. The cre sequence also included a nuclear localization signal (NLS) and the SV40 polyadenylation sequence. The purified construct was injected into pronuclei of fertilized B6xB6D2F1 oocytes. Two founders were obtained with both lines showing nearly identical patterns of cre expression. A generic line 1 was created as representative. (J:190530)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Neurod1     Summary of all recombinase alleles driven by Neurod1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:190530 Li HJ, et al., Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine. Dev Biol. 2012 Nov 15;371(2):156-69
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory