Rest^tm1.1Njb
Targeted Allele Detail

Summary

• Symbol: Rest^tm1.1Njb
• Name: RE1-silencing transcription factor; targeted mutation 1.1, Noel J Buckley
• MGI ID: MGI:5449435
• Synonyms: Rest^loxP
• Gene: Rest Location: Chr5:77413338-77434279 bp, + strand Genetic Position: Chr5, 41.61 cM
• Alliance: Rest^tm1.1Njb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190511
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:190511)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rest Mutation: 92 strains or lines available

References

• Original: J:190511 Soldati C, et al., Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation. Stem Cells. 2012 Mar;30(3):425-34
• All: 4 reference(s)