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Transgene Detail
Symbol: Tg(SOD1*)DF7Yaw
Name: transgene insertion DF7, Yasuhiro Watanabe
MGI ID: MGI:5449420
Synonyms: DF
Transgene: Tg(SOD1*)DF7Yaw  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(SOD1*)DF7Yaw expresses 1 gene
Mutation detailsThe transgene contains the entire genomic sequence of human SOD1 with a 2-bp deletion at codon 126 and a FLAG sequence at the C-terminal. The mutation causes a frame shift and results in premature stop sequence at codon 131, resulting in a mutant protein of 130 amino acids. No SOD1 activity could be detected, however, Western and Northern analysis indicated protein expression and presence of RNA, respectively. Two lines were established, DF2 and DF7. (J:97932)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:97932 Watanabe Y, et al., Mouse motor neuron disease caused by truncated SOD1 with or without C-terminal modification. Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):12-20
All:  1 reference(s)

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MGI 6.01
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