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Scribtm1.2Geno
Targeted Allele Detail
Nomenclature
Symbol: Scribtm1.2Geno
Name: scribbled planar cell polarity; targeted mutation 1.2, Genoway
MGI ID: MGI:5449168
Gene: Scrib  Location: Chr15:76047162-76069784 bp, - strand  Genetic Position: Chr15, 35.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190169
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 8 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 2 - 8. (J:190169)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scrib Mutation:  32 strains or lines available
References
Original:  J:190169 Hartleben B, et al., Role of the polarity protein Scribble for podocyte differentiation and maintenance. PLoS One. 2012;7(5):e36705
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory