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Rictortm1.1Klg
Targeted Allele Detail
Nomenclature
Symbol: Rictortm1.1Klg
Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.1, Kun-Liang Guan
MGI ID: MGI:5448837
Synonyms: RictorF
Gene: Rictor  Location: Chr15:6737860-6829882 bp, + strand  Genetic Position: Chr15, 3.25 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189736
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a loxP site followed by a frt-flanked neomycin resistance (neo) cassette upstream of exon 11, and a second loxP site downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exon 11 floxed. (J:189736, J:191342)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rictor Mutation:  92 strains or lines available
References
Original:  J:189736 Tang F, et al., A critical role for Rictor in T lymphopoiesis. J Immunol. 2012 Aug 15;189(4):1850-7
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory