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Mrgprb4tm3(cre)And
Targeted Allele Detail
Nomenclature
Symbol: Mrgprb4tm3(cre)And
Name: MAS-related GPR, member B4; targeted mutation 3, David J Anderson
MGI ID: MGI:5448562
Synonyms: Mrgprb4-cre, MrgprB4-mtdTomato-2A-NLScre-frt-PGK-neo-frt
Gene: Mrgprb4  Location: Chr7:47847961-47848926 bp, - strand  Genetic Position: Chr7, 31.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194547
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire open reading frame, encoded by a single exon, was replaced with an mtdTomato-2A-NLSCre-Frt-PGK-Neomycin-FRT cassette. The membrane-tagged tdTomato (mtdTomato) contains the 8 amino acids of the MARCKS sequence (MGCCFSKT) fused to the N-terminus of the full-length tdTomato and was connected to a nuclear localization signal (NLS)-tagged Cre recombinase via an intervening foot-and-mouth disease virus 2A peptide (FMDV 2A or F2A) sequence. (J:194547)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mrgprb4     Summary of all recombinase alleles driven by Mrgprb4.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mrgprb4 Mutation:  14 strains or lines available
References
Original:  J:194547 Vrontou S, et al., Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo. Nature. 2013 Jan 31;493(7434):669-73
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory