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Targeted Allele Detail
Symbol: Mrgprb4tm2.1And
Name: MAS-related GPR, member B4; targeted mutation 2.1, David J Anderson
MGI ID: MGI:5448560
Synonyms: MrgprB4-Tta-IRES-hPlap-ACN
Gene: Mrgprb4  Location: Chr7:47847961-47848926 bp, - strand  Genetic Position: Chr7, 31.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire open reading frame of the gene, encoded by a single exon, was replaced with a tTA-IRES-hPLAP-ACN targeting cassette. Tetracycline transactivator (Tta), an internal ribosome entry site (IRES), and human placental alkaline phosphatase (hPLAP) are fused with a self-excising loxP-flanked pol-II promoter-neomycin resistance cassette (ACN). Cre-mediated recombination removed the neo cassette. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mrgprb4 Mutation:  14 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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