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Tg(SOD1*G85R)#Roos
Transgene Detail
Nomenclature
Symbol: Tg(SOD1*G85R)#Roos
Name: transgene insertion, Raymond Roos
MGI ID: MGI:5448547
Synonyms: G85R
Transgene: Tg(SOD1*G85R)#Roos  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SOD1*G85R)#Roos expresses 1 gene
 
Mutation detailsThis transgene consists of the human SOD1 carrying a glycine to arginine substitution at amino acid 85 (G86R), a mutation associated with familial amyotrophic lateral sclerosis. In addition, loxP sites were engineered to flank the G86R sequence. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:147156)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:147156 Wang L, et al., Wild type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. Hum Mol Genet. 2009 Feb 19;18(9):1642-51
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory