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Targeted Allele Detail
Symbol: Scn1atm2.1Wac
Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 2.1, William A Catterall
MGI ID: MGI:5447489
Gene: Scn1a  Location: Chr2:66270778-66440840 bp, - strand  Genetic Position: Chr2, 39.13 cM
Germline Transmission:  Earliest citation of germline transmission: J:189897
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 25 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 25 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:189897)
Schematic representation of the targeting construct used to generate the Scn1atm2.1Wac allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scn1a Mutation:  64 strains or lines available
Original:  J:189897 Cheah CS, et al., Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14646-51
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory