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Tg(Th-Peo1*,-EGFP)2Gcor
Transgene Detail
Nomenclature
Symbol: Tg(Th-Peo1*,-EGFP)2Gcor
Name: transgene insertion 2, Gino A Cortopassi
MGI ID: MGI:5447072
Transgene: Tg(Th-Peo1*,-EGFP)2Gcor  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Th-Peo1*,-EGFP)2Gcor expresses 1 gene
 
Mutation detailsThe transgene contains 9.0 kb of upstream sequence from the rat tyrosine hydroxylase gene that drives dopamine neuron-specific expression of the mouse gene with a silent point mutation at position 1077 (c.1077C->G). This mutation forms a restriction enzyme site and allows for the insertion of 39 nucleotides that produces a duplication of amino acids 353 to 365. An IRES-EGFP and polyadenylation sequence follow the altered mouse gene. Four of six lines have higher EGFP expression than wild-type mice. Lines 1, 2, 3 and 4 contain 181, 227, 141, 97, 42 and 6 copies of the transgene, respectively. (J:188914)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:188914 Song L, et al., Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression. Hum Mol Genet. 2012 Dec 1;21(23):5147-58
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory