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Tg(Neurod2-Smo*A2)#Jols
Transgene Detail
Nomenclature
Symbol: Tg(Neurod2-Smo*A2)#Jols
Name: transgene insertion, James M Olson
MGI ID: MGI:5447065
Synonyms: ND2:SmoA2
Transgene: Tg(Neurod2-Smo*A2)#Jols  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Neurod2-Smo*A2)#Jols expresses 1 gene
 
Mutation detailsThe ND2:SmoA2 transgene contains the entire mouse smoothened homolog (Drosophila) Smo gene, with the constitutively active point mutation SmoA2 (S537N), driven by the 1kb mouse neurogenic differentiation 2 (Neurod2) promoter. Four lines were generated (221, 222, 225 and 242). All lines exhibit a low level of transgene expression (4-, 1-, 3- and 2-fold, respectively for each line relative to wild-type levels). The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:93861)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:93861 Hallahan AR, et al., The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 2004 Nov 1;64(21):7794-800
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory