Erbb3^{tm1.1(ERBB3)Mul}
Targeted Allele Detail

Summary

• Symbol: Erbb3^{tm1.1(ERBB3)Mul}
• Name: erb-b2 receptor tyrosine kinase 3; targeted mutation 1.1, William J Muller
• MGI ID: MGI:5446930
• Synonyms: ErbB3^delta85
• Gene: Erbb3 Location: Chr10:128403392-128425504 bp, - strand Genetic Position: Chr10, 77.1 cM
• Alliance: Erbb3^{tm1.1(ERBB3)Mul} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189292
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 12 through exon 16 was replaced by a construct containing a human cDNA with point mutations (A to T at the second codon position) that replace tyrosines with alanines at positions 941, 1054, 1197, 1222, 1260, 1276 and 1289 (within YXXM of the PI3K p85 concensus binding sites) and a floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:189292)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb3 Mutation: 47 strains or lines available

References

• Original: J:189292 Lahlou H, et al., Uncoupling of PI3K from ErbB3 impairs mammary gland development but does not impact on ErbB2-induced mammary tumorigenesis. Cancer Res. 2012 Jun 15;72(12):3080-90
• All: 1 reference(s)