Glp2r^tm1.2Xfg
Targeted Allele Detail

Summary

• Symbol: Glp2r^tm1.2Xfg
• Name: glucagon-like peptide 2 receptor; targeted mutation 1.2, Xinfu Guan
• MGI ID: MGI:5446803
• Synonyms: Glp2r^-
• Gene: Glp2r Location: Chr11:67554877-67661979 bp, - strand Genetic Position: Chr11, 41.13 cM
• Alliance: Glp2r^tm1.2Xfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189593
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 2. In situ hybridization and immunohistochemical analysis confirmed the absence of mRNA and protein in brain sections from homozygous mice. (J:189593)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glp2r Mutation: 39 strains or lines available

References

• Original: J:189593 Guan X, et al., GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab. 2012 Oct 1;303(7):E853-64
• All: 1 reference(s)