Sox1^{tm1.1(tTA)Blel}
Targeted Allele Detail

Summary

• Symbol: Sox1^{tm1.1(tTA)Blel}
• Name: SRY (sex determining region Y)-box 1; targeted mutation 1.1, Robert Blelloch
• MGI ID: MGI:5446381
• Synonyms: Sox1-tTA
• Gene: Sox1 Location: Chr8:12445519-12449555 bp, + strand Genetic Position: Chr8, 5.73 cM, cytoband A1-A2
• Alliance: Sox1^{tm1.1(tTA)Blel} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189006
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with a tetracycline transactivator (tTA) and polyadenylation sequence. Cre-mediated recombination removed the floxed neo cassette inserted downstream of the tTA. Immunohistochemistry confirmed the absence of protein expression. (J:189006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox1 Mutation: 13 strains or lines available

References

• Original: J:189006 Venere M, et al., Sox1 marks an activated neural stem/progenitor cell in the hippocampus. Development. 2012 Nov;139(21):3938-49
• All: 2 reference(s)