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Chemically induced Allele Detail
Symbol: Dnah11b2b1775Clo
Name: dynein, axonemal, heavy chain 11; Bench to Bassinet Program (B2B/CVDC), mutation 1775 Cecilia Lo
MGI ID: MGI:5446158
Synonyms: Blindfold, Dnahc11c.6489+2T
Gene: Dnah11  Location: Chr12:117877982-118199043 bp, - strand  Genetic Position: Chr12, 63.25 cM
Mutant 1775-005-LA displays dextrocardia, inverted lung lobe, malrotation of intestines

Show the 13 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Collection: B2B/CvDC
Allele Type:    Chemically induced (ENU)
Mutation:    Insertion
Mutation details
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnah11 Mutation:  12 strains or lines available
Summative Diagnosis:
Cardiovascular phenotypes: Dextrocardia associated with heterotaxy, duplicated IVC, inverted hemiazygous connection.
Non-cardiac phenotypes: Gut malroation, hypoplastic spleen, possible biliary obstruction. Dyskinetic and hyperkinetic airway cilia

Phenotypic Similarity to Human Syndrome: Heterotaxy, Primary Ciliary Dyskinesia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0100 Situs inversus totalis
0110 Dextrocardia
0190 Heterotaxy syndrome
2811 Absence of the suprarenal inferior vena cava with azygous continuation
4851 Kartagener syndrome (siewart syndrome)(primary ciliary dyskinesia)

Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program. MGI Direct Data Submission (B2B/CvDC). 2011-13;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.19
The Jackson Laboratory