About   Help   FAQ
Chemically induced Allele Detail
Symbol: Ccdc151b2b1885Clo
Name: coiled-coil domain containing 151; Bench to Bassinet Program (B2B/CVDC), mutation 1885 Cecilia Lo
MGI ID: MGI:5445347
Synonyms: Snowball
Gene: Ccdc151  Location: Chr9:21989871-22002634 bp, - strand  Genetic Position: Chr9, 8.01 cM, cytoband A4
Mutant 1885-003-LA displays situs inversus totalis

Show the 6 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThis ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to C substitution at nucleotide +2 of an intron following nucleotide 828 (c.828+2T>C), a presumed splicing mutation. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Ccdc151b2b1885Clo, and may be present in stocks carrying this mutation.
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccdc151 Mutation:  15 strains or lines available
Summative Diagnosis:
Cardiac phenotype: Dextrocardia associated with situs inversus totalis
Noncardiac phenotype: Hypoplastic spleen, adrenal anomaly, immotile/dyskinetic tracheal airway cilia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0100 Situs inversus totalis
0110 Dextrocardia
4851 Kartagener syndrome (siewart syndrome)(primary ciliary dyskinesia)

Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory