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Transgene Detail
Symbol: Tg(tetO-IL1B)KBry
Name: transgene insertion K, Kristina Bry
MGI ID: MGI:5444502
Synonyms: (tetO)7CMV-hIL-1beta
Transgene: Tg(tetO-IL1B)KBry  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
Tg(tetO-IL1B)KBry expresses 1 gene
Mutation detailsThis transgene contains the human IL1B cDNA coding for the active, mature protein which was inserted between seven copies of the tetracycline Operator (tetO)7-CMV minimal promoter and the bovine growth factor polyadenylation signals sequence. TetO, when present in cells also carrying a tetracycline transactivator (tTA) or reverse transactivator (rtTA) transgene, is inactivated or activated, respectively, by the administration of tetracycline or its analogue doxycycline. Three lines were made (K,L, and M) with line K showing highest human IL1B levels. (J:107601)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Phenotypic Similarity to Human Syndrome: Bronchopulmonary dysplasia (J:130523).
Original:  J:107601 Lappalainen U, et al., Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol. 2005 Apr;32(4):311-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory