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Tg(tetO-IL1B)KBry
Transgene Detail
Nomenclature
Symbol: Tg(tetO-IL1B)KBry
Name: transgene insertion K, Kristina Bry
MGI ID: MGI:5444502
Synonyms: (tetO)7CMV-hIL-1beta
Transgene: Tg(tetO-IL1B)KBry  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-IL1B)KBry expresses 1 gene
 
Mutation detailsThis transgene contains the human IL1B cDNA coding for the active, mature protein which was inserted between seven copies of the tetracycline Operator (tetO)7-CMV minimal promoter and the bovine growth factor polyadenylation signals sequence. TetO, when present in cells also carrying a tetracycline transactivator (tTA) or reverse transactivator (rtTA) transgene, is inactivated or activated, respectively, by the administration of tetracycline or its analogue doxycycline. Three lines were made (K,L, and M) with line K showing highest human IL1B levels. (J:107601)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: Bronchopulmonary dysplasia (J:130523).

References
Original:  J:107601 Lappalainen U, et al., Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol. 2005 Apr;32(4):311-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory