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Chemically induced Allele Detail
Symbol: Prss56glcr4
Name: protease, serine 56; glaucoma relevant mutation 4
MGI ID: MGI:5444189
Synonyms: Grm4, Prss56Grm4
Gene: Prss56  Location: Chr1:87183313-87188405 bp, + strand  Genetic Position: Chr1, 44.07 cM, cytoband C5
Strain of Origin:  C57BL/6J
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsENU induced a T to A transversion in exon 11, disrupting a splice donor site. This results in the retention of intron 11 in the transcript leading to a small insertion followed by a premature stop codon. Expression of the mRNA is higher in mutant eyes compared to wild-type eyes. (J:188765)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prss56 Mutation:  0 strains or lines available
Original:  J:188765 Nair KS, et al., Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 2011 Jun;43(6):579-84
All:  1 reference(s)

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MGI 5.21
The Jackson Laboratory