Nostrin^tm1.1Oess
Targeted Allele Detail

Summary

• Symbol: Nostrin^tm1.1Oess
• Name: nitric oxide synthase trafficker; targeted mutation 1.1, Stefanie Oess
• MGI ID: MGI:5444009
• Gene: Nostrin Location: Chr2:68966144-69019674 bp, + strand Genetic Position: Chr2, 39.58 cM
• Alliance: Nostrin^tm1.1Oess page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188414
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 4, exon 5 and the neo cassette. (J:188414)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nostrin Mutation: 36 strains or lines available

References

• Original: J:188414 Kovacevic I, et al., The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development. EMBO J. 2012 Aug 1;31(15):3309-22
• All: 2 reference(s)