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Ergtm1Poet
Targeted Allele Detail
Nomenclature
Symbol: Ergtm1Poet
Name: ETS transcription factor; targeted mutation 1, Peter Oettgen
MGI ID: MGI:5443836
Synonyms: ErgdeltaEx3
Gene: Erg  Location: Chr16:95359169-95586593 bp, - strand  Genetic Position: Chr16, 56.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188920
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a lacZ-neo cassette via homologous recombination. This mutation should abolish expression of isoforms 1 - 4 while retaining expression of isoforms 5 - 7. Strong LacZ expression is seen only in articular cartilage. (J:188920)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erg Mutation:  2 strains or lines available
References
Original:  J:188920 Vijayaraj P, et al., Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012 Nov;139(21):3973-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory