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Ano1tm1Jrr
Targeted Allele Detail
Nomenclature
Symbol: Ano1tm1Jrr
Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1, Jason Rock
MGI ID: MGI:5442019
Synonyms: Tmem16a::GFP
Gene: Ano1  Location: Chr7:144588549-144751974 bp, - strand  Genetic Position: Chr7, 88.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188769
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe endogenous stop codon was replaced with an amino acid polylinker RDPRVPVAT and EGFP to generate a fusion protein. A neo cassette was inserted downstream of the EGFP. (J:188769)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ano1 Mutation:  5 strains or lines available
References
Original:  J:188769 Huang F, et al., Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16354-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory