Peli3^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Peli3^tm1.1Arte
• Name: pellino 3; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5441750
• Gene: Peli3 Location: Chr19:4979745-4993155 bp, - strand Genetic Position: Chr19, 4.17 cM
• Alliance: Peli3^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188556
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and puro cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the puro cassette and exon 3. Semi-quantitative and real-time RT-PCR analysis confirmed the absence of mRNA expression in MEFs from homozygous embryos. (J:188556)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Peli3 Mutation: 22 strains or lines available

References

• Original: J:188556 Siednienko J, et al., Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. Nat Immunol. 2012 Nov;13(11):1055-62
• All: 4 reference(s)