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Wnt5atm1.1Tpy
Targeted Allele Detail
Nomenclature
Symbol: Wnt5atm1.1Tpy
Name: wingless-type MMTV integration site family, member 5A; targeted mutation 1.1, Terry P Yamaguchi
MGI ID: MGI:5440733
Synonyms: Wnt5aflox
Gene: Wnt5a  Location: Chr14:28504750-28527448 bp, + strand  Genetic Position: Chr14, 16.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187747
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP and FRT flanked inverted neo cassette was inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:187747)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnt5a Mutation:  7 strains or lines available
References
Original:  J:187747 Miyoshi H, et al., Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science. 2012 Oct 5;338(6103):108-13
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory