Map3k12^tm1.1Adia
Targeted Allele Detail

Summary

• Symbol: Map3k12^tm1.1Adia
• Name: mitogen-activated protein kinase kinase kinase 12; targeted mutation 1.1, Aaron DiAntonio
• MGI ID: MGI:5440722
• Synonyms: DLK^lox
• Gene: Map3k12 Location: Chr15:102406079-102425311 bp, - strand Genetic Position: Chr15, 57.63 cM, cytoband F3
• Alliance: Map3k12^tm1.1Adia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188476
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP cassette was inserted upstream of exon 8. An additional loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exons 8 through 11 floxed. These exons code the kinase domain. (J:188476)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k12 Mutation: 39 strains or lines available

References

• Original: J:188476 Miller BR, et al., A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci. 2009 Apr;12(4):387-9
• All: 8 reference(s)