Ngb^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Ngb^tm1.1Geno
• Name: neuroglobin; targeted mutation 1.1, Genoway
• MGI ID: MGI:5440445
• Gene: Ngb Location: Chr12:87144305-87149313 bp, - strand Genetic Position: Chr12, 41.29 cM, cytoband D3
• Alliance: Ngb^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188398
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstrea of exon 2 and an FRT flanked neo cassette and loxP site were introduced downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:187107, J:188398)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ngb Mutation: 9 strains or lines available

References

• Original: J:188398 Hundahl CA, et al., Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo. PLoS One. 2011;6(12):e28160
• All: 3 reference(s)