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Targeted Allele Detail
Symbol: Kpna1tm1.2Yyo
Name: karyopherin (importin) alpha 1; targeted mutation 1.2, Yoshihiro Yoneda
MGI ID: MGI:5439493
Synonyms: Impalpha5-
Gene: Kpna1  Location: Chr16:35983288-36037136 bp, + strand  Genetic Position: Chr16, 25.43 cM, cytoband B4-B5
Germline Transmission:  Earliest citation of germline transmission: J:188099
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsFlp-mediated recombination of Kpna1tm1Yyo removed exons 2 and 3. Western blot analysis confirmed the absence of protein expression in the brain, thymus, lung, heart, kidney, liver, spleen, testis and ovary. (J:188099)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kpna1 Mutation:  37 strains or lines available
Original:  J:188099 Moriyama T, et al., Targeted disruption of one of the importin alpha family members leads to female functional incompetence in delivery. FEBS J. 2011 May;278(9):1561-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory