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Rnf43tm1Cle
Targeted Allele Detail
Nomenclature
Symbol: Rnf43tm1Cle
Name: ring finger protein 43; targeted mutation 1, Hans Clevers
MGI ID: MGI:5439364
Gene: Rnf43  Location: Chr11:87662722-87735539 bp, + strand  Genetic Position: Chr11, 52.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186765
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of the exons encoding the RING finger domain and a loxP site and FRT flanked neo cassette were inserted downstream of these exons via homologous recombination. (J:186765)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnf43 Mutation:  2 strains or lines available
References
Original:  J:186765 Koo BK, et al., Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature. 2012 Aug 30;488(7413):665-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory