Prox1^tm1.1Fuma
Targeted Allele Detail

Summary

• Symbol: Prox1^tm1.1Fuma
• Name: prospero homeobox 1; targeted mutation 1.1, Fumio Matsuzaki
• MGI ID: MGI:5438824
• Synonyms: Prox1-C:EGFP, Prox1^F
• Gene: Prox1 Location: Chr1:189850232-189902911 bp, - strand Genetic Position: Chr1, 95.85 cM
• Alliance: Prox1^tm1.1Fuma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187615
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed mouse cDNA, EGFP, and FRT-flanked neo cassette replaced the coding sequence in exon 2. Flp-mediated recombination removed the neo cassette. (J:187615)

Expression

In Mice Carrying this Mutation:	113 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prox1 Mutation: 43 strains or lines available

References

• Original: J:187615 Iwano T, et al., Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus. Development. 2012 Aug;139(16):3051-62
• All: 6 reference(s)