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Targeted Allele Detail
Symbol: Prox1tm1.1Fuma
Name: prospero homeobox 1; targeted mutation 1.1, Fumio Matsuzaki
MGI ID: MGI:5438824
Synonyms: Prox1F
Gene: Prox1  Location: Chr1:190118035-190170714 bp, - strand  Genetic Position: Chr1, 95.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:187615
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed mouse cDNA, EGFP, and FRT-flanked neo cassette replaced the coding sequence in exon 2. Flp-mediated recombination removed the neo cassette. (J:187615)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prox1 Mutation:  7 strains or lines available
Original:  J:187615 Iwano T, et al., Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus. Development. 2012 Aug;139(16):3051-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory